Project

Mechanistic insights into the role of the WEE1 kinase upon replication stress

Code
3G0C7214
Duration
01 January 2014 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Plant biology
Keywords
WEE1 Arabidopsis DNA stress
 
Project description

Plants lacking WEE1 display normal development under control growth conditions, but are hypersensitive towards replication-inhibitory drugs. The underlying reasons for this hypersensitivity are currently unknown. Through the mapping of WEE1 complementation mutants we aim to uncover the mechanisms that account for the replication drug hypersensitivity of WEE1 deficient plants. In parallel, we aim to study WEE1 at the post-transcriptional level.