Research Explorer

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Project

Mechanistic insights into the role of the WEE1 kinase upon replication stress

Outputs and Outcomes

Code

3G0C7214

Duration

01 January 2014 → 31 December 2019

Funding

Research Foundation - Flanders (FWO)

Promotor

Lieven De Veylder

Research disciplines

Natural sciences
- Plant biology

Keywords

WEE1 Arabidopsis DNA stress

Project description

Plants lacking WEE1 display normal development under control growth conditions, but are hypersensitive towards replication-inhibitory drugs. The underlying reasons for this hypersensitivity are currently unknown. Through the mapping of WEE1 complementation mutants we aim to uncover the mechanisms that account for the replication drug hypersensitivity of WEE1 deficient plants. In parallel, we aim to study WEE1 at the post-transcriptional level.

English

Dutch

English

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