Research Explorer

Project

The isotopic composition of serum Cu as a diagnostic and prognostic marker for liver disease – unraveling the role of Cu and identification of the factors governing its isotopic composition.
Code
01IO0216
Duration
01 October 2016 → 31 July 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Instrumental methods
  • Medical and health sciences
    • Hepatology
Keywords
Isotopic analysis Copper Metabolism Liver disease Multi-collector ICP-mass spectrometry
 
Project description
 

The goal of this interdisciplinary research project is unraveling the role of Cu in liver disease and identification of the factors governing Cu isotope ratio variation by using mouse models and by further development of analytical methods. With these methods, we will have access to information on the isotopic composition of bulk Cu and of Cu in selected fractions and species, while we will also be able to reveal the spatial distribution of Cu and variation in 65Cu/63Cu down to a (sub-)cellular level.