This research challenges the 50-year CDK-centric cell cycle paradigm by demonstrating MPK4 as an independent master regulator of cellular resilience. Our chemical-inducible MPK4 system enables precise spatiotemporal control, revealing concentration-dependent functional separation: 10μM treatment disrupts cell cycle without affecting stress responses. We will screen 50,000 EMS mutants using innovative chemical-genetic fusion methodology, employ TurboID-AP/MS for dynamic protein interactions, and validate findings across species (moss, tomato, human). This pioneering work establishes "resilience biology" as a new discipline, transforms fundamental understanding of growth-defense coordination, and provides agricultural applications for climate-resistant crops. Expected outcomes include paradigm-shifting discoveries in cell biology, novel biotechnological tools, and comprehensive molecular networks governing eukaryotic survival strategies.