Research Explorer

Project

MOR(e) partners in crime: a bioassay approach to study μ-opioid receptor dimerization by new synthetic opioids
Code
01D30022
Duration
01 October 2022 → 31 October 2022
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Characterisation of biologically active (macro)molecules
    • Cell signaling
  • Medical and health sciences
    • Biomolecular modelling and design
    • Forensic toxicology
Keywords
New Synthetic opioids MOR dimerization Bioassays Structure-activity relationship
 
Project description

The emergence of new synthetic opioids (NSO) poses a serious threat to public health. This project aims at investigating the concept of μ-opioid receptor (MOR) dimerization, based on recent findings that a class of NSO induces MOR dimerization. An optimized MOR-MOR interaction assay will be developed, and the mechanisms of MOR dimerization will be elucidated via modelling of MOR dimers.