Research Explorer

Project

Cell-free nucleic acid profiling in diffuse large B-cell lymphoma: a molecular guidance to precision medicine
Code
01D23222
Duration
01 October 2022 → 31 October 2022
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
    • Transcriptomics
  • Medical and health sciences
    • Cancer biology
    • Cancer diagnosis
Keywords
cell-free RNA diffuse large B-cell lymphoma liquid biopsy multi-omics
 
Project description
 

Total RNA sequencing is performed on matched tissue and plasma samples within a human DLBCL cohort to identify (circulating) biomarkers, linked to phenotype, response, and prognosis. Complementary, cell-free RNA (cfRNA) is explored in a patient-derived DLBCL xenograft model, enabling step-by-step dissection of the circulating transcriptome in tumor-, immune-, and stromal cellderived fractions. Lastly, a multi-omics analysis will compare cfRNA with available cfDNA copy number and methylation patterns.