Glioblastoma is the most common and most aggressive malignant brain tumour in adults.  Even with the current state-of-the-art treatment consisting of maximal surgical resection followed by combined radiotherapy and chemotherapy, the median survival is only 12-14 months. Since the introduction of temozolomide, now more than 15 years ago, no significant improvements have been made in the treatment of these tumours. Therefore, new therapeutic strategies are urgently needed.  

Dose painting is a radiation oncology technique that considers the molecular and biological tumour heterogeneity and redistributes the total prescribed irradiation dose within the tumour according to the biological differences determined with PET imaging. Areas of higher PET-activity can be planned to a higher dose. The underlying hypothesis is that a higher dose to these more active areas will result in an increased chance of cell kill and finally better tumour control and survival.