Code
01D11922
Looptijd
01-10-2022 → 31-10-2023
Financiering
Regional and community funding: Special Research Fund
Promotor
Onderzoeksdisciplines
-
Medical and health sciences
- Innate immunity
- Virology
-
Agricultural and food sciences
- Veterinary immunology
- Veterinary microbiology
Trefwoorden
Herpesvirus
pseudorabies virus
UL13 kinase
porcien
NK cel
NKG2D
liganden
Projectomschrijving
We recently discovered that the viral UL13 kinase of the porcine alphaherpesvirus PRV triggers downregulation of ligands for the activating NK cell receptor NKG2D, which complicates the antiviral activity of NK cells. Aim of the application is to (i) unravel the underlying mechanism, (ii) investigate
whether this effect is conserved in other (alpha)herpesviruses and (iii) identify novel porcine NKG2D ligands.