Research Explorer

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Project

A detailed study of the role of SRC-1A and SRC-2 (GRP-1) in TNF-induced Glucocorticoid Resistance

Outputs and Outcomes

Code

01J00511

Duration

01 July 2011 → 30 April 2016

Funding

Regional and community funding: Special Research Fund

Promotor

Claude Libert

Research disciplines

Medical and health sciences
- Immunology
- Morphological sciences
- Oncology
- Respiratory medicine
- Immunology
- Morphological sciences
- Oncology
- Respiratory medicine
- Immunology
- Morphological sciences
- Oncology
- Respiratory medicine

Keywords

mice liver inflammation biology sepsis

Project description

It is our hypothesis that the reduced glucocorticoid response of many patients suffering from inflammation, is due to effects of TNF on the biology of the glucocorticoid receptor. In this project, we will investigate whether the effects of TNF are located at the level or activity of the GR-cofactors SCR1 and SRC2.

English

Dutch

English

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