Project

Role of the mycobacterial cell wall lipids, myocolic acids, in the control of ontracellular replication of mycobacterium tuberculasis bacilli

Code
3GA09210
Duration
01 November 2010 → 31 October 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
mycolic acid mycobacterium tuberculosis macrophage cholesterol
 
Project description

With this aim to develop new therapeutic approaches to (drug-resistant- tuberculosis, we aim to wetermine how mycobacterial cell wall mycolic acids interfere ith the host cell function and hereby facilitate intracellular replication of the bacilli. Using mouse models, the interrelation between mycolic acids-facilitated intracellular replication, disturbed macrophage cholesterol metabolic pathways and the cholesteroid nature of mycolic acids will be verified.