Supramolecular structure-function relationship of naturally occurring antimicrobial peptides.

01 March 2013 → 31 December 2017
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Analytical chemistry
    • Organic chemistry
    • Physical chemistry
NMR x-ray diffraction supramolecular chemistry antibiotics
Project description

Very little is known about the structure-function relationship of the class of antimicrobial peptides known as CLPs, short for cyclic lipodepepsipeptides. Thanks to recently developed NMR methodology within our lab, we demonstrated that self-assmebly of the CLP pseudodesmin A into larger supramolecular, pore-like structures, provides the structural basis to explain its biological activity. This proposition is further explored in our project.