Project

Study of human lymphoid cell differentiation using gene-modified embryonic stem cells and induced pluripotent stem cells from immunodeficiency patients

Duration
01 January 2011 → 31 October 2015
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
  • Medical and health sciences
    • Gynaecology and obstetrics
    • Immunology
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Immunology
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Immunology
    • Molecular and cell biology
    • Morphological sciences
Keywords
immunity gene targeting immune deficiency embryonic stem cells induced pluripotent stem cells human hematopoiesis
 
Project description

Pluripotent stem cells will be generated from patients with an inborn immune (T/NK) deficiency. In addition, gene modified human embryonic stem cells will be generated for lineage tracing and deletion mutants. Using these cell lines T and NK differentiation will be studied and the effect of the targeted genes on differentiation will be analyzed.