Chronic, nonclosing wounds are a common lesion in equines and are prone to complications such as exuberant granulation tissue (EGT) development. The exact mechanisms that trigger the condition are still not completely understood increasing the difficulty of developing an effective treatment. Fish skin has high collagen I fiber content, which has chemotactic properties, being beneficial for wound healing. Alginates are used to develop hydrogel dressings capable of high exudate absorption together with their ability to deliver active compounds to the area, among other things. Both biomaterials can be obtained from aquatic sources, contributing to a more sustainable circular economy. The proposed research project aims to develop a collagen-alginate (CA) blend-based hydrogel to treat equine wounds to prevent EGT development. To that end, collagen and alginate will be extracted from rainbow trout (Onchorhynchus mykiss) skin and Sargassum muticum seaweed respectively, chemically characterized and subsequently processed into (CA) blends. The developed materials will be subjected to an in-depth characterization using state-of-the-art devices, antibacterial tests and in vitro biocompatibility assays. The wound healing efficacy of the blends will be explored in in-vitro, ex vivo and in vivo assays. The results of this research will provide useful data towards the development of wound-dressing to effectively treat EGT.