Due to increasing concerns about the negative impact of chemical plant protection products (PPPs) use in the management of plant diseases and pests, more stringent regulations on plant protection products application have been implemented at the EU level. These regulations mandate the adoption of "Integrated Pest Management (IPM)” prioritizing low-chemical PPP-input strategies. In this context, there is growing interest in the use of biobased plant defense elicitors (PDEs) to enhance plant immunity and protect crops against diseases and pest insects. The unique complementary expertise of the participating research groups led to the discovery of novel biobased PDEs, being lignocellulose-based compounds derived from waste/side streams of natural materials. Stable and consistent preparation of these compounds is achieved through controlled and novel catalytic fractionation processes. Laboratory assays demonstrated that these compounds have great potential to fortify the innate resilience of plants against both biotic and abiotic stresses, outperforming commercial induced resistance (IR)-eliciting molecules. In this project, we aim to: (i) Assess whether compounds from a specific plant species trigger a stronger defense response when applied to the same species compared to a different species, and investigate their IR-activity against a range of major diseases and insect pests; (ii) Structurally identify the IR-eliciting molecules within the active fractions and evaluate purely synthesized IR-eliciting counterparts; (iii) Conduct environmental fate and ecotoxicity tests, and perform initial ecological risk assessments; (iv) Optimize IR efficacy, including formulation and stability improvements, application methods, dose-response studies, in-depth mode of action (MOA) studies, and combinations with other (chemical) PPPs; (v) Perform small-scale field trials to evaluate effectiveness under real-world conditions.