Chronic rhinosinusitis is a heterogenous group of chronic airways diseases that display a high comorbidity with asthma. Evidence has accumulated showing that S100A8/A9 proteins and HMGB1 can regulate the function of immune cells and modulate inflammatory responses via RAGE and TLRs. With this project we aim to investigate the contribution of these molecules in the pathology and persistence of inflammation in human upper airway conditions which remains unexplored.