Research Explorer

Project

The interdependent role of metallothioneins and hypoxia-inducible factor and its relevance in experimental inflammatory bowel disease
Code
01D20510
Duration
01 October 2010 → 13 January 2015
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Gastro-enterology and hepatology
    • Gastro-enterology and hepatology
Keywords
metallothioneins inflammatory bowel disease hypoxia-inducible factor
 
Project description

Metallothioneins (MTs) are proteins whose role in inflammatory bowel diseases (IBD) is only poorly understood. An aberrant expression of MTs in IBD patients has been demonstrated by our group. Recent data from literature provide evidence for an interrelationship between MTs and hypoxia. We wish to further elucidate the relationship between MTs and hypoxia and its functional relevance in IBD.