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Project

Involvement of the endoplasmic reticulum stress response in lung dendritic cell function and inflammatory lung disease

Outputs and Outcomes

Acronym

lung DCs unfold

Code

41MC3310

Duration

14 October 2011 → 13 October 2013

Funding

European funding: framework programme

Promotor

Bart Lambrecht

Research disciplines

Medical and health sciences
- Immunology
- Immunology
- Immunology

Keywords

lung inflammation dendritic cell ER stress

Project description

Dendritic cells (DCs) are essential for the pathogenesis of inflammatory lung diseases. Many environmental triggers of lung diseases induce endoplasmic reticulum (ER) stress in lung cells.

We hypothesize that ER stress is an endogenous danger signal in DCs, which will impact in the development of lung inflammation. This project will unveil the relevance of the ER stress in lung DC subsets in vivo.

English

Dutch

English

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