Involvement of the endoplasmic reticulum stress response in lung dendritic cell function and inflammatory lung disease

lung DCs unfold
14 October 2011 → 13 October 2013
European funding: framework programme
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
lung inflammation dendritic cell ER stress
Project description

Dendritic cells (DCs) are essential for the pathogenesis of inflammatory lung diseases. Many environmental triggers of lung diseases induce endoplasmic reticulum (ER) stress in lung cells.

We hypothesize that ER stress is an endogenous danger signal in DCs, which will impact in the development of lung inflammation. This project will unveil the relevance of the ER stress in lung DC subsets in vivo.