Multiplexed biosensing technologies can bring an important impact to the medical practice reflecting more accurately the health status and favouring a quicker, more accurate, and early detection of a disease by maximizing the amount of information that can be obtained.

The project aims to develop a new biosensing technology based on micro/nano-systems for performing reliably and efficiently monitoring of multiple key biological biomarkers of the immune system, linked with health conditions such as cancer.

The project comprises the fabrication of nanodevices, surface bio-functionalization of the devices, electrical characterization of the devices prior and after the surface treatment, integration of the biosensing elements with supporting readout electronics and the implementation and validation of the complete system for biosensing applications. Specifically, biosensing experiments will be conducted for the detection and the monitoring of the concentration in interstitial fluid and/or blood of multiple biomarkers. One of the main aims of the research will be to optimize the bio-sensors considering the aspects of high selectivity, high sensitivity, low false positive and false negative rates as well as to investigate the interrelation of the biomarkers under study in cases of cancer.