As tablets account for more than 80% of all pharmaceutical preparations cost- and time-efficient
development of a tablet formulation is essential. Specifically the transition from small-scale tablet
manufacturing (i.e. during early phases of product development when only limited amounts of
material is available) towards full-scale manufacturing is challenging as process settings between
both conditions cannot automatically be transferred. Hence, this project aims to correlate the
observations during small-scale tablet manufacturing (using the Styl’One Evolution tableting
machine) with the tableting conditions during full-scale tableting (using the Modul™ P rotary tablet
press), focusing on the impact of process settings during tableting on critical quality aspects of
tablets. This will facilitate scale-up of tablet manufacturing within the pharmaceutical industry,
thus improving the efficiency of drug development and reducing the time-to-market of a new drug
product formulated as a tablet.