As tablets account for more than 80% of all pharmaceutical preparations cost- and time-efficient development of a tablet formulation is essential. Specifically the transition from small-scale tablet manufacturing (i.e. during early phases of product development when only limited amounts of material is available) towards full-scale manufacturing is challenging as process settings between both conditions cannot automatically be transferred. Hence, this project aims to correlate the observations during small-scale tablet manufacturing (using the Styl’One Evolution tableting machine) with the tableting conditions during full-scale tableting (using the Modul™ P rotary tablet press), focusing on the impact of process settings during tableting on critical quality aspects of tablets. This will facilitate scale-up of tablet manufacturing within the pharmaceutical industry, thus improving the efficiency of drug development and reducing the time-to-market of a new drug product formulated as a tablet.