Project

Expansion and osteogenic differentiation of human embryonic stem cells in bone regeneration

Duration
01 January 2008 → 31 October 2012
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
  • Medical and health sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Orthopaedics
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Orthopaedics
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Orthopaedics
Keywords
osteogenesis bone regeneration human embryonic stem cells cell delivery feeder-free
 
Project description

Human embryonic stem cells are expanded in vitro without the use of feeder-layers. After expansion cells are differentiated into the osteogenic lineage using specific culture conditions and selection of subpopulations. Teratoma formation and ectopic bone formation are evaluated in vivo in immunodeficient mice.