Link between hypoxia and progenitor cells in liver carcinogenesis.

01 January 2013 → 31 December 2018
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Hepatology
hepatocellular carcinoma progenitor cell Notch pathway cholangiocellular carcinoma hypoxia
Project description

Primary liver cell cancer (hepatocellular carcinoma and cholangiocarcinoma) evolve from a liver progenitor cell. Depending on different pathways (eg Notch pathway) and in the presence or absence of oxygen, these cells can dedifferentiate towards a tumor with hepatocytic or cholangiocytic aspects. These pathways shall be studied in this project.