Code
3G033313
Duration
01 January 2013 → 31 December 2018
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Medical and health sciences
- Hepatology
Keywords
hepatocellular carcinoma
progenitor cell
Notch pathway
cholangiocellular carcinoma
hypoxia
Project description
Primary liver cell cancer (hepatocellular carcinoma and cholangiocarcinoma) evolve from a liver progenitor cell. Depending on different pathways (eg Notch pathway) and in the presence or absence of oxygen, these cells can dedifferentiate towards a tumor with hepatocytic or cholangiocytic aspects. These pathways shall be studied in this project.