The current PhD project is focusing on the development of novel bioadhesive synthetic polymers able to rapidly photo-crosslink upon visible light irradiation for the treatment of photodamaged aging tissues. Moreover, light-responsive delivery of natural active ingredients is also targeted for their beneficial effects regarding anti-aging and UV-protective properties. To this end, thiolactone ring-opening and subsequent thiol Michael addition will be performed to obtain well-defined block-co-polymers constituting polyether and polysiloxane chains bearing multiple carboxylic reactive groups to be subjected to further modification towards the incorporation of coumarin-derived photo-cleavable active compounds, linear and branched photo-crosslinkable functionalities and photo-initiators active in the visible range. Additionally, biopolymers-derived crosslinkers will be developed via chemical functionalization of natural polymers. The developed polymers (synthetic and nature-derived) will be characterized with the aid of spectroscopic and chromatographic techniques. The above-mentioned polymers will be crosslinked upon visible light irradiation to develop purely synthetic or hybrid films for which the photo-crosslinking degree and -kinetics will be assessed. Mechanical and adhesive properties of the novel materials will be determined along with their surface tension value, release capabilities of incorporated active ingredients as well as biocompatibility.