Research Explorer

Project

Enhancing Chiral Separation through Optically Active Solvents and Comprehensive Two-Dimensional Liquid Chromatography with Water-Rich Mobile Phases in the First Dimension
Code
01CD12424
Duration
07 September 2024 → 06 March 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Analytical separation and detection techniques
    • Instrumental methods
 
Project description
 One project aspect involves studying optically active solvents in the mobile phase, which serve as both modifiers and chiral selectors in chiral chromatography. Another focuses on using LC × LC for complex sample analysis, addressing modulation issues by employing water-rich mobile phase techniques like TRLC and PALC in the first dimension. TRLC × Chiral is developed, and PALC × Chiral is being optimized for analyzing chiral pharmaceuticals in biological fluids.