Research Explorer

Project

Translational research on the role of the Hedgehog pathway; ADAM19 and HTR4 in the pathogenesis of COPD
Code
01D27910
Duration
01 October 2010 → 30 September 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Respiratory medicine
    • Respiratory medicine
    • Respiratory medicine
Keywords
ADAM19 Hedgehog pathway HTR4 COPD
 
Project description

Recently, a Genome Wide Association study on lung function has identified 8 genetic loci that are associated with the ratio of the forced respiratory volume in one second (FEV1) to the forced vital capacity (FVC). We investigate the role of 3 genes - Hedgehog Interacting Protein (HHIP); a disingretin and metallopeptidase domain 19 (ADAM19) and 5-hydroxytryptaminereceptor 4 (HTR4) - in a mousemodel of COPD and in human subjects.