the consortium presents a joint program to investigate at the tissue, cellular and molecular level teh expression, function and regulation of a umber of ion channels, transporters and ionotropic receptors underlying normal and abnormal excitability in the heart and CNS. A number of shared and conserved properties of these molecules across different types of excitable cells justify and facilitate the use of common platforms and knowledge basis, whereas the unique function in different tissues enriches the exxchange and collaboration between the different partners.