Modeling gene regulatory network evolution through gene duplication from a mechanistic perspective

01 January 2015 → 31 December 2020
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Scientific computing
    • Bioinformatics and computational biology
    • Evolutionary biology
    • General biology
    • Plant biology
  • Medical and health sciences
    • Bioinformatics and computational biology
    • Bioinformatics and computational biology
    • Public health care
    • Public health services
    • Social medical sciences
    • Bioinformatics and computational biology
  • Engineering and technology
    • Scientific computing
genotype-phenotype mapping evolution of biological systems gen(om)e duplication mechanistic modeling
Project description

We will use fine-grained, sequence-based genotype-phenotype mapping models in combination with population-based evolutionary algorithms to study the evolution of molecular systems through gen(om)e duplication under stabilizing, directional and fluctuating selection. We will in particular study the mechanisms by which duplicates in gene regulatory networks may diverge, and the impact of duplications on the origin of emergent system properties.