This project aims to provide insight into the role of SF3B2 in the pathogenesis of autosomal dominant retinitis pigmentosa (adRP). Following research questions are addressed: where does WT SF3B2 localize in adult human and mouse retina? What are the pathogenic consequences of the SF3B2 mutations in cellular models? What are the pathogenic consequences of SF3B2 mutations in vivo? Can trans-acting mutations of SF3B2 be identified in a larger cohort of adRP patients?