Provoked vestibulodynia is characterized by mechanical (and thermal) allodynia localized to the mucosa of the vaginal vestibule. Histopathologically, this appears to involve hyperinnervation (increased subepithelial or intraepithelial nociceptive Aδ and C nerve fibers) and inflammation, as suggested by animal models where inflammation triggers hyperinnervation. However, human studies are inconsistent, and the specific cells involved (e.g., mast cells) remain unclear. With nearly 200 vestibulectomies annually, we have substantial material to better describe the histopathology of vestibulodynia and further investigate the role of the inflammasome.