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Project

Hybrid ionizable polymer-lipid mRNA delivery systems for intratumoral immunotherapy

Information

Project Team

Organisations

Outputs and Outcomes

Publications

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong ChenEmily De LombaerdeAimee-Rose Bugler-LambZifu ZhongMartijn SchuijsClaudia Mariela Brenis GómezJamie De BaereMark GontsarikHeleen LauwersKim DeswarteNiek SandersBart LambrechtMartin GuilliamsBruno De Geest et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2025

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan LienenklausBart LambrechtNiek SandersBruno De Geest et al.

A1 Journal Article in ACS NANO

2024