Project

Study of mediators and pathways contributing to chronic pain in Ehlers-Danlos syndrome

Duration
01 October 2016 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Laboratory medicine
    • Medical systems biology
    • Neurosciences
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Neurosciences
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Neurosciences
Keywords
chronic pain Ehlers-Danlos syndrome mouse models
 
Project description

This project aims to gain more insights into the molecular origins and mechanisms that initiate and maintain chronic pain in Ehlers-Danlos syndrome (EDS). To this purpose, we will study pain-related behavior in EDS animal models, analyse the concomittant changes in innervation and pain pathways and evaluate the pronociceptive potential of extracellular matrix proteins secreted by patient fibroblast cultures.