The aim of our study is twofold: (1) to investigate the neural correlates of pantomiming tool use and explore the factors that influence its lateralization, and (2) to determine how knowledge about tools and their use is distributed in the brain. The first aim will be achieved by tool pantomiming paradigms involving different tasks performed by different groups of normal volunteers in an fMRI study. The second aim will be tackled in a lesion-function study by presenting a test battery of tool use knowledge to apraxic patients with well-documented lesions.