Polarization-resolved interferometric scattering microscopy

01 May 2023 → 30 April 2027
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Classical and physical optics
    • Photonics, optoelectronics and optical communications
  • Engineering and technology
    • Nanophotonics
    • Biophotonics
polarization Microscopy Optical materials light scattering
Project description

In this project, we will build an interferometric scattering microscope with polarization resolution. Interferometric scattering microscopy is a recent technique that exploits the interference between scattered light from a small object and reflected light from a substrate to create contrast for samples as small as a single protein. We will apply the microscope to image and characterize the morphology of nanoscale objects of interest in the field of biochemistry, amongst other potential applications. The goal is to obtain quantitative information about the size and three-dimensional conformation of a variety of samples by adding fine polarization measurements to interferometric scattering microscopy.