Research Explorer

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Project

Clinical validation of new targets for the inhibition of HIV replication.

Outputs & Impact

Publications & research data ( 14 )

Evolution of the HIV-1 integration site landscape and inducible reservoir in early-treated people

Tine StruyveMarion PardonsJozefien De ClercqLiesbet TermoteLaurens LambrechtsYtse NoppeMathias LichterfeldSofie RutsaertLinos Vandekerckhove

A1 Journal Article in PLOS PATHOGENS

Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Marion PardonsLaurens LambrechtsYtse NoppeLiesbet TermoteSofie De BraekeleerJerel VegaEllen Van GulckSarah GerloLinos Vandekerckhove

A1 Journal Article in NATURE COMMUNICATIONS

Integrative assessment of total and intact HIV-1 reservoir by a 5-region multiplexed rainbow DNA digital PCR assay

Mareva DelporteLaurens LambrechtsEvy BlommeWillem van SnippenbergSofie RutsaertMaxime VerschooreEvelien De SmetYtse NoppeNele De LangheMarie-Angélique De Scheerder et al.

A1 Journal Article in CLINICAL CHEMISTRY

Interactome of the HIV-1 proteome and human host RNA

Tinus SchynkelWillem van SnippenbergKimberly VerniersGwendolyn M. JangNevan J. KroganPieter MestdaghLinos VandekerckhoveWim Trypsteen

A1 Journal Article in EMBO REPORTS

Staging of immuno-virological dynamics during acute HIV infection in a Belgian prospective cohort study

Jozefien De ClercqMarie-Angélique De ScheerderSophie VanherrewegeEls CaluweNathalie MoreelsDanny DeloozeAnnemieke DhondtMarc CoppensStefaan J. VandecasteeleSabine D. Allard et al.

A1 Journal Article in JOURNAL OF VIRUS ERADICATION

Development of human innate immune responses in a humanized mouse model expressing four human myelopoiesis transgenes

Hannah StocksElisabeth De LeeuwBart LambrechtLinos VandekerckhoveGeert van LooAndy Wullaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Longitudinal patterns of inflammatory mediators after acute HIV infection correlate to intact and total reservoir

Jozefien De ClercqMarie-Angélique De ScheerderVirginie MortierChris VerhofstedeStefaan J. VandecasteeleSabine D. AllardCoca NecsoiStephane De WitSarah GerloLinos Vandekerckhove

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Marion PardonsBasiel ColeLaurens LambrechtsWillem van SnippenbergSofie RutsaertYtse NoppeNele De LangheAnnemieke DhondtJerel VegaFilmon Eyassu et al.

A1 Journal Article in NATURE COMMUNICATIONS

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

A1 Journal Article in NUCLEIC ACIDS RESEARCH

No significant association between 25-OH vitamin D status and SARS-VoV-2 antibody response after COVID-19 vaccination in nursing home residents and staff

Eline MeyersEvelien De SmetHanne VercruysseSteven CallensElizaveta PadalkoStefan HeytensLinos VandekerckhovePiet CoolsWojciech Witkowski

A1 Journal Article in VACCINES

Evaluating lncRNA expression patterns during HIV-1 treatment interruption

Tinus SchynkelWillem van SnippenbergClarissa Van HeckeLinos VandekerckhoveWim Trypsteen

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption

Basiel ColeLaurens LambrechtsZoe BoyerYtse NoppeMarie-Angélique De ScheerderJohn-Sebastian EdenBram VranckenTimothy E. SchlubSherry McLaughlinLisa M. Frenkel et al.

A1 Journal Article in CELL REPORTS

Distinct immune profiles of HIV‐infected subjects are linked to specific lipid mediator signature

Magdalena SipsSarah GerloLaura De ClercqEsteban A. GomezRomain A. ColasJesmond DalliLinos Vandekerckhove

A1 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

Measuring proviral HIV-1 DNA : hurdles and improvements to an assay monitoring integration events utilising human alu repeat sequences

Eva MalatinkováJordan ThomasWard De SpiegelaereSofie RutsaertAnna Maria GerettiGeorgios PollakisWilliam A. PaxtonLinos VandekerckhoveAlessandra Ruggiero

A1 Journal Article in LIFE-BASEL

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )