Research Explorer

Project

Research into the role and mechanism of caspase-7 in immunomodulation and in immunopathologies
Code
3F008608
Duration
01 October 2008 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
inflammation mouse model caspase-7
 
Project description

Recent experimental data within our unit suggests a differential role for caspase-3 and -7. Conditional caspase-7 deficient mice were generated to be able to further investigate these findings. These mice will be used in certain murine experimental pathology models (EAE, I/R) and derived cells will be used for ex-vivo experiments to clarify the non-redundant role of caspase-7.