Functional analysis of the NBPF gene family with a putative tumor suppressiverole in different human cancers

01 October 2008 → 30 September 2009
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Morphological sciences
    • Morphological sciences
functional analysis tumor suppressor gene neuroblastoma
Project description

A constitutional translocation in a neuroblasoma patient identified a new gene, NBPF1. In this project, we want to investigate the tumor suppressive role of NBPF1. For this, we will use an inducible cell system and RNA interference. We will also perform endogenous immunoprecipitations and the identification of specific partners will further elucidate the possible functions of NBPF1.