Research Explorer

Project

Alternative pathways of cellular CD4 trafficking and functional relevance in hematopoietic cells
Code
3F016310
Duration
01 October 2010 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Hematology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Hematology
    • Immunology
    • Laboratory medicine
Keywords
CD4 RNAi hematopoietic cells
 
Project description

The CD4 receptor expressed on hematopoietic cells is essential in T cell development and activation and is down-modulated during T cell activation or pathological conditions like HIV-1 infection, but the process is still poorly understood. In this project, genes involved in CD4 down-modulation identified by a genome-wide shRNA screening are validated and evaluated for their functional relevance in hematopoietic cells.