A precision medicine approach for canine degenerative myelopathy combining genetic and epigenetic alterations

01 January 2019 → 31 December 2022
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal genetics
    • Epigenetics
    • Epigenomics
  • Social sciences
    • Neuropsychology
    • Neurocognitive patterns and neural networks
    • Cognitive ageing
  • Medical and health sciences
    • Epigenetics
    • Neurological and neuromuscular diseases
    • Neurological and neuromuscular diseases
    • Epigenetics
    • Neurophysiology
  • Agricultural and food sciences
    • Veterinary genetics
    • Other veterinary sciences not elsewhere classified
    • Agricultural, veterinary and food sciences not elsewhere classified
Precision medicine (epi)genetics degenerative myelopathy
Project description

This project aims to introduce precision medicine and epigenetics research in the canine neurogenetics field. Practically, canine degenerative myelopathy will be studied with MBD-seq to identify differentially methylated regions associated with disease progression. This will be followed by the writing of a general statistical analysis framework in R that accurately predicts clinical age ofonset for this disorder.