Project

Evaluation of the risk of resistance development against antivirulence therapy

Duration
01 January 2019 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Immunology
    • Laboratory medicine
    • Microbiology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
quorum sensing interference. selective pressure. Fitness
 
Project description

Antivirulence therapy is a promising novel method to control (antibiotic resistant) infections. In this respect, interfering with quorum sensing, bacterial cell-to-cell communication, is the most intensively investigated strategy. There still is debate with respect to the risk of resistance
development against such a strategy. In this project, we will evaluate this risk in a host-pathogen model system.