Research Explorer

Project

Evaluation of the risk of resistance development against antivirulence therapy
Code
01N00119
Duration
01 January 2019 → 31 December 2022
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Virology
    • Microbiomics
  • Medical and health sciences
    • Immunogenetics
    • Clinical genetics and molecular diagnostics
Keywords
quorum sensing interference. selective pressure. Fitness
 
Project description
 

Antivirulence therapy is a promising novel method to control (antibiotic resistant) infections. In this respect, interfering with quorum sensing, bacterial cell-to-cell communication, is the most intensively investigated strategy. There still is debate with respect to the risk of resistance
development against such a strategy. In this project, we will evaluate this risk in a host-pathogen model system.