Project

The induction of intestinal immunity in a piglet model

Duration
01 January 2015 → 31 December 2020
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Plant biology
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
retinoic acid intradermal immunisation targeting oral immunisation
 
Project description

Oral immunisation offers many advantages, however epithelial barriers hamper antigen uptake. To trigger intestinal immunity in pigs, antigen uptake will be enhanced via oral administration of plant--‐produced antibody--‐antigen constructs selectively targeted to an epithelial transcytotic receptor. In parallel, to circumvent oral administration, intradermal immunization in the presence of retinoic acid should allow switching the skin’s immune system towards intestinal immunity.