Project

Discovery of renal biomarkers to detect early chronic kidney disease in cats

Code

01CD06024

Duration

01 November 2024 → 30 April 2025

Funding

Regional and community funding: Special Research Fund

Promotor

Sylvie Daminet

Fellow

Ellen Vanden Broecke

Research disciplines

Medical and health sciences
- Biomarker discovery
- Kidney diseases
Agricultural and food sciences
- Veterinary internal medicine and pathophysiology

Keywords

optimization biomarkers validation profiling fingerprinting feline chronic kidney disease Metabolomics

Project description

Early biomarkers for feline chronic kidney disease (CKD) are lacking. This study: (i) aims to optimize and validate a serum and urine UHPLC-HRMS protocol, ii) leverages the power of (un)targeted metabolomics to discover novel biomarkers in both matrices and iii) validates the selected markers and panels in a longitudinal cohort of healthy cats that developed CKD.