This doctoral research proposal investigates the unique relationship between the bacterial capsular serotype, bacteriophage-encoded depolymerases that degrade capsular exopolysaccharides and the bacteriophage host spectrum, specifically for Klebsiella pneumoniae bacteriophages. The enzymatic properties of these exopolysaccharide depolymerases will be analysed. A first-in-class phage engineering method will be introduced to study the role of these enzymes in the tail fibers of bacteriophages