Discovery and functional analysis of TP53 network long non-coding RNA genes in cancer

01 October 2012 → 01 October 2014
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Project description

Following the Nobel price winning discovery of microRNAs, a new class of

regulatory long non-coding RNAs has recently come into the picture. It is assumed

that these novel genes play vital roles in cellular regulatory mechanisms. Elucidation

of the specific lncRNA functions will have a major impact on our understanding of

cellular processes and can provide a significant contribution towards development of

treatments for many diseases. In this context, the aim of my postdoctoral research

project is to identify cancer related lncRNAs in the TP53 governed cellular network.

By means of advanced experimental and bioinformatics procedures, I will study

lncRNA function, putative protein interaction partners, and DNA binding sites. By

mapping lncRNAs in the TP53 pathway, processes utilized by tumors to evade TP53

induced apoptosis and senescence programs will be clarified, ultimately resulting in

identification of targets for molecular anti-cancer therapies.