Project

The role of angiopoietin signaling on the regulation of angiogenesis by TIE2 expressing macrophages

Code

01N02818

Duration

01 January 2018 → 31 December 2021

Funding

Regional and community funding: Special Research Fund

Promotor

Ward De Spiegelaere

Research disciplines

Natural sciences
- Animal biology
- Genetics
Medical and health sciences
- Cardiac and vascular medicine
- Cardiac and vascular medicine
- Cardiac and vascular medicine
Agricultural and food sciences
- Veterinary medicine

Keywords

Angiogenesis Macrophages TIE2

Project description

TIE2 expressing macrophages (TEMs) are important regulators of angiogenesis, i.e. the growth and remodeling of blood vessels. TEMs regulate initial blood vessel growth, but are also active during vascular remodeling and maturation. In this project we will investigate whether a balance between the TIE2 ligands, angiopoietin-1 and angiopoietin-2 drives TEMs to a pro-angiogenesis or a vessel maturation phenotype.