Project

The role of angiopoietin signaling on the regulation of angiogenesis by TIE2 expressing macrophages

Code
01N02818
Duration
01 January 2018 → 31 December 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
  • Medical and health sciences
    • Cardiac and vascular medicine
    • Cardiac and vascular medicine
    • Cardiac and vascular medicine
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
Angiogenesis Macrophages TIE2
 
Project description

TIE2 expressing macrophages (TEMs) are important regulators of angiogenesis, i.e. the growth and remodeling of blood vessels. TEMs regulate initial blood vessel growth, but are also active during vascular remodeling and maturation. In this project we will investigate whether a balance between the TIE2 ligands, angiopoietin-1 and angiopoietin-2 drives TEMs to a pro-angiogenesis or a vessel maturation phenotype.