Chronic disease is associated with a substantial burden both for the patient and their environment. The QAPICHE study provides a profound insight into the Health-related quality of life (HRQoL) of chronically ill patients, by comparing patient groups and investigating the determinants, accounting
for multimorbidity and socioeconomic status. Furthermore, the interrelation between patients’ HRQoL and informal caregivers’ HRQoL is investigated.