Research Explorer

Project

Evaluation of 5-HT4 receptor agonism in central and peripheral in vitro models
Code
179S1211
Duration
01 December 2010 → 31 May 2013
Funding
Private funding via IWT/VLAIO
Research disciplines
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Neurosciences
    • Gastro-enterology and hepatology
    • Neurosciences
    • Gastro-enterology and hepatology
    • Neurosciences
Keywords
atrium 5-HT4 receptor hippocampus intestine stomach
 
Project description
 

Newly synthetized 5-HT4 receptor agonists are tested in different electrophysiological protocols in rat hippocampal brain slices. Effects at peripheral 5-HT4 receptors are tested in rat esophageal muscularis mucosae, guinea pig proximal colon and porcine proximal stomach and left atrium.