Project

Dissection of the HIV reservoir in acutely infected patients treated immediately

Code

01J14917

Duration

01 October 2017 → 30 September 2023

Funding

Regional and community funding: Special Research Fund

Promotor

Linos Vandekerckhove

Research disciplines

Medical and health sciences
- Immunology not elsewhere classified

Keywords

HIV reservoir early cART acute seroconversion replication-competent reservoir clonal proliferation

Project description

In this HIV cure research project we will determine the composition of the replication competent reservoir in specific T memory cells in early treated acute seroconverters and study the clonal expansion as a driver of persistent HIV infection. This will be done by mapping sequences of the complete HIV genome, by determining integration sites in the human genome at different time points and by transcriptome analysis on T memory cells at single cell level.