Project

Dissection of the HIV reservoir in acutely infected patients treated immediately

Code
01J14917
Duration
01 October 2017 → 30 September 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology not elsewhere classified
Keywords
HIV reservoir early cART acute seroconversion replication-competent reservoir clonal proliferation
 
Project description

In this HIV cure research project we will determine the composition of the replication competent reservoir in specific T memory cells in early treated acute seroconverters and study the clonal expansion as a driver of persistent HIV infection. This will be done by mapping sequences of the complete HIV genome, by determining integration sites in the human genome at different time points and by transcriptome analysis on T memory cells at single cell level.