Project

The role of the IRE-­1/XBP-­1 axis in NK cell mediated anti-­tumor immunology

Duration
01 October 2017 → 30 September 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
Keywords
NK cells, tumor immunology, UPR, IRE ­1, XBP ­1
 
Project description

This project aims to identify the role of the unfolded protein response in NK cell homeostasis and functioning. More specifically, we will address the function of the IRE-­1/XBP-­1 axis in NK cell mediated anti-­tumor responses in vivo. This research question is highly novel and will lead to a better understanding of NK cellbiology, which is highly relevant for cancer immunotherapy.