Research Explorer

Project

Hydrophilic thermoplastic polyurethanes for the manufacturing of innovative highly dosed oral sustained release matrices
Code
3S019816
Duration
01 January 2016 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Pharmaceutical technology
Keywords
TPU sustained release matrices HME melt granulation
 
Project description

Sustained release dosage forms have been successfully developed via HME using different polymers; the drug load in these formulations is often low. With high drug loads (>40%) burst release or processing issues are observed. Therefore the design of novel sustained release dosage forms using innovative polymeric (TPU) materials with improved characteristics is investigated during this project.