Code
01CD13423
Duration
01 November 2023 → 30 April 2024
Funding
Regional and community funding: Special Research Fund
Research disciplines
-
Medical and health sciences
- Rhinology
Keywords
neutrophils
Chronic rhinosinusitis
nasal polyps
eosinophils
biologicals
inflammation
Project description
Chronic rhinosinusitis with nasal polyps is subdivided in a type 2-high and type 2-low endotype. The type 2-high group is well-defined by eosinophilic markers, while the type 2-low group is highly variable. First, we identified markers for the second group in mice and human. Next, we investigated the change from a high to low endotype after treatment with biologicals.